Mechanism of Action Archives - CureVac

mRNA-Based Vaccines and Mode of Action

by Bettina Joedicke-Braas

Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

mRNA mediates passive vaccination against infectious agents, toxins, and tumors

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals

mRNA-based vaccines synergize with radiation therapy to eradicate established tumors