• Data to be presented includes CV8102 as a single agent and in combination with anti-PD1 therapy

TÜBINGEN, Germany / BOSTON, MA, USA – November 7, 2018

CureVac AG, a fully integrated biopharmaceutical company pioneering the field of mRNA-based drugs, today announced it will present preliminary data from its Phase I dose-escalation clinical trial with the RNA-based cancer therapy, CV8102, in patients with advanced solid tumors. These data will be presented as a poster presentation at the 2018 Society of Immunotherapy of Cancer (SITC) Annual Meeting in Washington, DC, Nov. 7-11, 2018.

Poster Presentation Details

Title: Phase I dose-escalation and expansion study of intratumoral CV8102, a RNA-based TLR- and RIG-1 agonist with or without anti-PD1 antibodies in patients with advanced solid tumors

Session: Friday, November 9, 2018, 12:45 PM-2:15 PM and 6:30 PM-8:00pm EST

Poster Number: P337; Location: Hall E, Walter E. Washington Convention Center

About CV8102 and the Phase I Clinical Trial

CV8102, a TLR7/8/RIG-1 agonist based on noncoding single stranded RNA, is designed to modulate the tumor microenvironment after intratumoral injection and to induce a systemic immune response to control injected as well as non-injected distant lesions.

The CV8102 phase I, open-label, dose escalation and expansion study is enrolling patients with advanced melanoma, cutaneous squamous cell carcinoma, squamous cell carcinoma of head and neck, or adenoidcystic carcinoma and superficially injectable tumor lesions.

The trial is currently enrolling patients at multiple clinical sites in Germany. The trial tests escalating doses of single agent CV8102 and CV8102 in combination with licensed anti-PD-1 antibodies.

The primary objective of the study is to assess safety and tolerability. Secondary objectives are to assess clinical efficacy and changes in various immune parameters in blood and tumor tissue.

About CureVac AG

CureVac is a leading clinical stage biotechnology company in the field of messenger RNA (mRNA) technology with 20 years of expertise in developing and optimizing this versatile molecule for medical purposes. The principle of CureVac’s proprietary technology is the use of mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a wide range of diseases. The company applies its technologies for the development of cancer therapies, antibody therapies, the treatment of rare diseases, and prophylactic vaccines. CureVac has received significant investments, amongst others from dievini Hopp BioTech holding and the Bill & Melinda Gates Foundation. CureVac has also entered into collaborations with multinational corporations and organizations, including Boehringer Ingelheim, Eli Lilly & Co, Genmab, CRISPR Therapeutics, the Bill & Melinda Gates Foundation, CEPI and others. CureVac is headquartered in Tübingen, Germany with sites in Frankfurt and Boston, USA.

For more information, please visit www.curevac.com or follow us on Twitter at @CureVacAG.

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